Construction has started on Mercy Hospital Wentzville, Missouri’s first new acute care hospital campus in nearly a decade.
The project involves construction of the 400,000-square-foot hospital, which is expected to include 75 inpatient acute care beds and a 26-bed emergency department with two trauma areas and four behavioral health rooms. The campus will offer a broad range of inpatient and outpatient care to the region, including surgical and specialty options such as cardiovascular, cancer and orthopedics, as well as outpatient imaging, diagnostic and treatment services.
Crews began preparing the site in late March and will begin work on the central utility plant this summer, with the hospital tower work beginning in early 2026. Construction of the hospital is expected to be completed in four years. Project partners include McCarthy Building Companies, CannonDesign and IMEG.


